Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the neural cell adhesion molecule and polysialic acid in human neuroblastoma cell lines

10 May 2011

Abstract excerpt

The neural cell adhesion molecule NCAM is a cell surface glycoprotein of the immunoglobulin superfamily and is widely expressed in tumours of neuroectodermal origin such as neuroblastoma. NCAM can be decorated by the carbohydrate polymer polysialic acid (polySia), which attenuates NCAM-mediated cell adhesion and increases cellular motility. The key enzymes in the biosynthesis of polySia are the two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Hypoxia, and Metabolism
Share to Glycosylation and Glycoproteins Research
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21567084
DOI: 10.3892/ijo.2011.1038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the neural cell adhesion molecule and polysialic acid in human neuroblastoma cell linesPMID 21567084Read ↗

Polysialic acid directs tumor cell growth by controlling heterophilic neural cell adhesion molecule interactions.Semantic proximity Read ↗

Pharmacological Inhibition of polysialyltransferase ST8SiaII Modulates Tumour Cell MigrationSemantic proximity Read ↗

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environmentSemantic proximity Read ↗

Neural cell adhesion molecule (NCAM) isoform expression is associated with neuroblastoma differentiation statusSemantic proximity Read ↗

Polysialylated neural cell adhesion molecules expressed in human pituitary tumors and related to extrasellar invasionSemantic proximity Read ↗

Molecular characterization of eukaryotic polysialyltransferase-1.Semantic proximity Read ↗

N-Cadherin in Neuroblastoma Disease: Expression and Clinical SignificanceSemantic proximity Read ↗

NCAM expression induces neurogenesis in vivo.Semantic proximity Read ↗

ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes.Semantic proximity Read ↗

Polysialyltransferase-1 autopolysialylation is not requisite for polysialylation of neural cell adhesion molecule.Semantic proximity Read ↗

Genetic ablation of polysialic acid causes severe neurodevelopmental defects rescued by deletion of the neural cell adhesion molecule.Semantic proximity Read ↗

Molecular defects that cause loss of polysialic acid in the complementation group 2A10.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.