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Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment

9 Sept 2016

Abstract excerpt

Polysialic acid (polySia) is a unique carbohydrate polymer expressed on the surface of NCAM (neuronal cell adhesion molecule) in a number of cancers where it modulates cell-cell and cell-matrix adhesion, migration, invasion and metastasis and is strongly associated with poor clinical prognosis. We have carried out the first investigation into the effect of polySia expression on the behaviour of cancer cells in...

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PMID: 27611649
DOI: 10.1038/srep33026

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