Article
Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation.
Scientific reports - 27 Jul 2018
Lorach H, Kang S, Dalal R, Bhuckory M B, Quan Y, Palanker D
Abstract excerpt
MERTK mutation reduces the ability of retinal pigment epithelial (RPE) cells to phagocytize the photoreceptor outer segments, which leads to accumulation of debris separating photoreceptors from RPE cells, resulting in their degeneration and loss of vision. In a rat model of Retinitis Pigmentosa due to MERTK mutation, we demonstrate that surgical removal of debris performed when about half of photoreceptors are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.