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Article

Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration.

Experimental eye research - 1 Feb 2018

LaVail Matthew M, Nishikawa Shimpei, Steinberg Roy H, Naash Muna I, Duncan Jacque L, Trautmann Nikolaus, Matthes Michael T, Yasumura Douglas, Lau-Villacorta Cathy, Chen Jeannie, Peterson Ward M, Yang Haidong, Flannery John G

Abstract excerpt

We produced 8 lines of transgenic (Tg) rats expressing one of two different rhodopsin mutations in albino Sprague-Dawley (SD) rats. Three lines were generated with a proline to histidine substitution at codon 23 (P23H), the most common autosomal dominant form of retinitis pigmentosa in the United States. Five lines were generated with a termination codon at position 334 (S334ter), resulting in a C-terminal...

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Source

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Identifiers

PMID: 29122605
DOI: 10.1016/j.exer.2017.10.023
PMCID: PMC5811379

Genes

ERG
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration.PMID 29122605Read ↗

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