Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.

Investigative ophthalmology & visual science - 1 Sept 2008

Corrochano Silvia, Barhoum Rima, Boya Patricia, Arroba Ana I, Rodríguez-Muela Natalia, Gómez-Vicente Violeta, Bosch Fátima, de Pablo Flora, de la Villa Pedro, de la Rosa Enrique J

Abstract excerpt

PURPOSE: Retinitis pigmentosa (RP) is a heterogeneous group of inherited conditions that lead to blindness and for which there is no effective therapy. Apoptosis of photoreceptors is a common feature in animal models of the disease. Thus, the authors studied the therapeutic potential of proinsuli...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroretinography

Share to Mice, Inbred Strains

Share to Proinsulin

Share to Retinal Degeneration

Share to Retinitis Pigmentosa

Share to Vision Disorders

Source

Identifiers

PMID: 18515565
DOI: 10.1167/iovs.08-2182

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18515565-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa.PMID 18515565Read ↗

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosaSemantic proximity Read ↗

Programmed Cell Death in Retinal Degeneration: Targeting Apoptosis in Photoreceptors as Potential Therapy for Retinal DegenerationSemantic proximity Read ↗

Molecular mechanisms underlying inherited photoreceptor degeneration as targets for therapeutic interventionSemantic proximity Read ↗

PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in <i>rd1</i> mouse inherited retinal degenerationSemantic proximity Read ↗

Mechanisms of apoptosis in retinitis pigmentosa.Semantic proximity Read ↗

Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant rats.Semantic proximity Read ↗

Neuroprotective Strategies for the Treatment of Inherited Photoreceptor DegenerationSemantic proximity Read ↗

Autosomal dominant Retinitis Pigmentosa caused by the rhodopsin isoleucine 255 deletion features rapid neuroretinal degeneration, decreased synaptic connectivity, and neuroinflammationSemantic proximity Read ↗

RGR-Mediated Photopic Visual Cycle and Oxidative Stress: Potential Mechanisms for Cone Vision Impairment and Retinal Degeneration in Retinitis Pigmentosa Linked to D1080N-IRBP.Semantic proximity Read ↗

Retinitis Pigmentosa Results in Neurodegeneration Concomitant With Neuroinflammation, Extracellular Matrix Disorganization and the Upregulation of Neuroprotective Pathways in Glial Cells and NeuronsSemantic proximity Read ↗

The use of induced pluripotent stem cells to reveal pathogenic gene mutations and explore treatments for retinitis pigmentosa.Semantic proximity Read ↗

Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 DiabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.