Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pigment Epithelium-Derived Factor (PEDF) Fragments Prevent Mouse Cone Photoreceptor Cell Loss Induced by Focal Phototoxicity In Vivo

30 Sept 2020

Abstract excerpt

Here, we evaluated the effects of PEDF (pigment epithelium-derived factor) and PEDF peptides on cone-photoreceptor cell damage in a mouse model of focal LED-induced phototoxicity (LIP) in vivo. Swiss mice were dark-adapted overnight, anesthetized, and their left eyes were exposed to a blue LED placed over the cornea. Immediately after, intravitreal injection of PEDF, PEDF-peptide fragments 17-mer, 17-mer[H105A]...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Photoreceptor and optogenetics research
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33008127
DOI: 10.3390/ijms21197242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pigment Epithelium-Derived Factor (PEDF) Fragments Prevent Mouse Cone Photoreceptor Cell Loss Induced by Focal Phototoxicity In VivoPMID 33008127Read ↗

H105A peptide eye drops promote photoreceptor survival in murine and human models of retinal degenerationSemantic proximity Read ↗

Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo.Semantic proximity Read ↗

Inhibitory peptide of mitochondrial μ-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats.Semantic proximity Read ↗

Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration.Semantic proximity Read ↗

Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potentialSemantic proximity Read ↗

Photoreceptor degeneration in microphthalmia (Mitf) mice: partial rescue by pigment epithelium-derived factorSemantic proximity Read ↗

Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degenerationSemantic proximity Read ↗

Pigment Epithelium-Derived Factor Gene Therapy Targeting Retinal Ganglion Cell Injuries: Neuroprotection against Loss of Function in Two Animal ModelsSemantic proximity Read ↗

Biphasic photoreceptor degeneration induced by light in a T17M rhodopsin mouse model of cone bystander damage.Semantic proximity Read ↗

Identification of miRNAs in a Model of Retinal DegenerationsSemantic proximity Read ↗

Long-term Rescue of Photoreceptors in a Rodent Model of Retinitis Pigmentosa Associated with MERTK Mutation.Semantic proximity Read ↗

Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.