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Article

Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.

Investigative ophthalmology & visual science - 6 Apr 2012

Deng Wen-Tao, Dinculescu Astra, Li Qiuhong, Boye Sanford L, Li Jie, Gorbatyuk Marina S, Pang Jijing, Chiodo Vince A, Matthes Michael T, Yasumura Douglas, Liu Li, Alkuraya Fowzan S, Zhang Kang, Vollrath Douglas, LaVail Matthew M, Hauswirth William W

Abstract excerpt

PURPOSE: The absence of Mertk in RCS rats results in defective RPE phagocytosis, accumulation of outer segment (OS) debris in the subretinal space, and subsequent death of photoreceptors. Previous research utilizing Mertk gene replacement therapy in RCS rats provided proof of concept for treatment of this form of recessive retinitis pigmentosa (RP); however, the beneficial effects on retinal function were...

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Share to c-Mer Tyrosine Kinase
Share to Electroretinography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Injections

Share to Microscopy, Electron, Transmission

Share to Rats, Mutant Strains

Share to Retinal Pigment Epithelium

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Source

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Identifiers

PMID: 22408006
DOI: 10.1167/iovs.11-8831
PMCID: PMC3995567

Genes

MERTK
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.PMID 22408006Read ↗

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