Article
Identification of tonsillar CD4+CD25-LAG3+ T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue.
Journal of autoimmunity - 1 Jan 2017
Sumitomo Shuji, Nakachi Shinichiro, Okamura Tomohisa, Tsuchida Yumi, Kato Rika, Shoda Hirofumi, Furukawa Asayo, Kitahara Nobuo, Kondo Kenji, Yamasoba Tatsuya, Yamamoto Kazuhiko, Fujio Keishi
Abstract excerpt
IL-10-producing regulatory T cells (IL-10-producing Tregs) are one of the regulatory T cell subsets characterized by the production of high amounts of IL-10, the lack of FOXP3 expression and the strong immunosuppressive capabilities. IL-10-producing Tregs have been primarily reported as induced populations thus far, in part because identifying naturally occurring IL-10-producing Tregs was difficult due to the...
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