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Article

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.

Blood - 2 May 2013

Abdel-Wahab Omar, Levine Ross L

Abstract excerpt

Recent studies of the spectrum of somatic genetic alterations in acute myeloid leukemia (AML) have identified frequent somatic mutations in genes that encode proteins important in the epigenetic regulation of gene transcription. This includes proteins involved in the modification of DNA cytosine...

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Topics

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Share to Dioxygenases
Share to DNA-Binding Proteins
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methyltransferase 3A

Share to Epigenesis, Genetic

Share to Genes, Modifier

Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 23640996
DOI: 10.1182/blood-2013-01-451781
PMCID: PMC3643757

Genes

ASXL1
IDH1
IDH2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23640996-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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