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Article

The role of mutations in epigenetic regulators in myeloid malignancies.

Nature reviews. Cancer - 1 Sept 2012

Shih Alan H, Abdel-Wahab Omar, Patel Jay P, Levine Ross L

Abstract excerpt

Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative neoplasms (MPNs), myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). In some cases these mutations occur in genes with known roles in regulating chromatin and/or methylation states in haematopoietic progenitors, and in other cases genetic and functional...

Topics

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DNA Methyltransferase 3A
Epigenomics
ASXL1 gene
DNMT3A gene
IDH2 gene
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Myeloproliferative Disorders

Source

Identifiers

PMID: 22898539
DOI: 10.1038/nrc3343

Genes

ASXL1
DNMT3A
IDH1
IDH2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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