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Article

An essential type I nitroreductase from Leishmania major can be used to activate leishmanicidal prodrugs.

The Journal of biological chemistry - 4 Oct 2013

Voak Andrew A, Gobalakrishnapillai Vithurshaa, Seifert Karin, Balczo Edina, Hu Longqin, Hall Belinda S, Wilkinson Shane R

Abstract excerpt

Nitroaromatic prodrugs are used to treat a range of microbial infections with selectivity achieved by specific activation reactions. For trypanosomatid parasites, this is mediated by type I nitroreductases. Here, we demonstrate that the causative agent of leishmaniasis, Leishmania major, expresses an FMN-containing nitroreductase (LmNTR) that metabolizes a wide range of substrates, and based on electron donor and...

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Identifiers

PMID: 23946481
DOI: 10.1074/jbc.M113.494781
PMCID: PMC3789948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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