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Article

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

1 Jul 2012

Abstract excerpt

Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of prodrugs widely used to treat bacterial and trypanosome infections, but despite relative specificity, 5-nitrofurans often cause serious toxic side effects in people. Here, we use yeast and zebrafish, as well as human in vitro systems, to assess the biological...

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PMID: 22840776
DOI: 10.1016/j.chembiol.2012.05.017

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