Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways.

Experimental parasitology - 1 Nov 1997

Hardy L W, Matthews W, Nare B, Beverley S M

Abstract excerpt

The study of antifolate-resistant mutants of the protozoan parasite Leishmania has provided useful information about genetic processes such as gene amplification and mutation and knowledge of the unique features of the pteridine metabolic pathway in this primitive eukaryote. The novel bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) is an essential enzyme, yet most DHFR-TS inhibitors show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Drug Resistance
Share to Microbial Sensitivity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multienzyme Complexes

Share to Mutation

Share to Oxidoreductases

Share to Species Specificity

Share to Tetrahydrofolate Dehydrogenase

Source

Identifiers

PMID: 9371081

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways.PMID 9371081Read ↗

The Roles of Pteridine Reductase 1 and Dihydrofolate Reductase-Thymidylate Synthase in Pteridine Metabolism in the Protozoan Parasite Leishmania majorSemantic proximity Read ↗

Folate metabolic pathways in <i>Leishmania</i>Semantic proximity Read ↗

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.Semantic proximity Read ↗

PTR1-dependent synthesis of tetrahydrobiopterin contributes to oxidant susceptibility in the trypanosomatid protozoan parasite Leishmania major.Semantic proximity Read ↗

Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.Semantic proximity Read ↗

Increased transport of pteridines compensates for mutations in the high affinity folate transporter and contributes to methotrexate resistance in the protozoan parasite Leishmania tarentolae.Semantic proximity Read ↗

Dihydrofolate Reductase as a Target for Chemotherapy in ParasitesSemantic proximity Read ↗

Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.Semantic proximity Read ↗

Bifunctional thymidylate synthase‐dihydrofolate reductase in protozoaSemantic proximity Read ↗

Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in miceSemantic proximity Read ↗

Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.Semantic proximity Read ↗

Isolation and characterization of a mutant dihydrofolate reductase-thymidylate synthase from methotrexate-resistant Leishmania cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.