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Article

Phenotypic-Based Discovery and Exploration of a Resorufin Scaffold with Activity against Mycobacterium tuberculosis.

ChemMedChem - 16 Dec 2024

Tran Eric, Cheung Chen-Yi, Li Lucy, Carter Glen P, Gable Robert W, West Nicholas P, Kaur Amandeep, Gee Yi Sing, Cook Gregory M, Baell Jonathan B, Jörg Manuela

Abstract excerpt

Tuberculosis remains a leading cause of death by infectious disease. The long treatment regimen and the spread of drug-resistant strains of the causative agent Mycobacterium tuberculosis (Mtb) necessitates the development of new treatment options. In a phenotypic screen, nitrofuran-resorufin conjugate 1 was identified as a potent sub-micromolar inhibitor of whole cell Mtb. Complete loss of activity was observed...

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Identifiers

PMID: 39248310
DOI: 10.1002/cmdc.202400482
PMCID: PMC11648835

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