Article
Identification of a type I nitroreductase gene in non-virulent Trypanosoma rangeli.
Memorias do Instituto Oswaldo Cruz - 1 Jul 2017
Montenegro Marjorie, Cuervo Claudia, Cardenas Constanza, Duarte Silvia, Díaz Jenny R, Thomas M Carmen, Lopez Manuel C, Puerta Concepcion J
Abstract excerpt
Trypanosomatid type I nitroreductases (NTRs), i.e., mitochondrial enzymes that metabolise nitroaromatic pro-drugs, are essential for parasite growth, infection, and survival. Here, a type I NTR of non-virulent protozoan Trypanosoma rangeli is described and compared to those of other trypanosomatids. The NTR gene was isolated from KP1(+) and KP1(-) strains, and its corresponding transcript and 5' untranslated...
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