Article
Assessing the Essentiality of Leishmania donovani Nitroreductase and Its Role in Nitro Drug Activation
4 Dec 2012
Abstract excerpt
The nitroimidazole fexinidazole has potential as a safe and effective oral drug therapy for the treatment of visceral leishmaniasis. To date, nitroheterocyclics have not been used in the treatment of leishmaniasis, and relatively little is known about their mechanism of action. In African trypanosomes, nitro drugs are reductively activated by a type I nitroreductase (NTR), absent in mammalian cells. Modulation of...