Article

Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection

2022-04-06

Abstract excerpt

Tuberculosis remains one of the leading causes of death from a single infectious agent, surpassing both AIDS and malaria. In recent years, two bicyclic nitroimidazole drugs, delamanid and pretomanid have been approved to treat this airborne infection. This has spurred a renewed interest in developing new and improved nitroimidazole analogs. We have previously identified a new bicyclic heteroaromatic subclass, the...

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Literature Corpus work: 5edac48d-abe1-507c-bf50-c52417d4fe41
DOI: 10.1101/2022.04.05.487095

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