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Article

Common KRAS and NRAS gene mutations in sporadic colorectal cancer in Northeastern Iranian patients.

Current problems in cancer - 1 Nov 2018

Hamzehzadeh Leila, Khadangi Fatemeh, Ghayoor Karimiani Ehsan, Pasdar Alireza, Kerachian Mohammad Amin

Abstract excerpt

OBJECTIVES: Mutation analysis of the Epidermal Growth Factor Receptor downstream has been a main part of colorectal carcinoma evaluation. Large prospective clinical trials have shown only colorectal cancer (CRC) with wild-type KRAS and NRAS responds to anti-Epidermal Growth Factor Receptor treatment. Hence, mutation analysis is necessary prior to treatment. It is essential to conduct studies to learn about the...

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Identifiers

PMID: 29921458
DOI: 10.1016/j.currproblcancer.2018.05.001

Genes

KRAS
NRAS

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