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Article

Sustained response to deep brain stimulation in LRRK2 parkinsonism with the Y1699C mutation.

Journal of Parkinson's disease - 1 Jan 2012

Perju-Dumbrava L D, McDonald M, Kneebone A C, Long R, Thyagarajan D

Abstract excerpt

Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. We present an affected individual from the Lincolnshire pedigree (Y1699C), on whom bilateral STN-DBS was performed to control severe motor fluctuations and dyskinesias. He showed a...

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PMID: 23938256
DOI: 10.3233/JPD-012121

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