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Article

Effective long-term subthalamic stimulation in PARK8 positive Parkinson's disease.

Journal of neurology - 1 Jul 2010

Breit Sorin, Wächter T, Schmid-Bielenberg D, Weiss D, Leitner P, Nägele T, Freudenstein D, Gasser T, Krüger R

Abstract excerpt

Whether patients with genetically defined Parkinson's disease (PD) may be particularly eligible to benefit from deep brain stimulation of the nucleus subthalamicus (STN-DBS) is currently the subject of debate. We report on a patient with advanced PD due to R793M missense mutation in the LRRK2 gene successfully treated by STN-DBS. Disease onset was at age 42 with bradykinesia, rigidity and rest tremor. During the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20177695
DOI: 10.1007/s00415-010-5493-8

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