Article
Bilateral subthalamic stimulation in Parkin and PINK1 parkinsonism.
Neurology - 1 Apr 2008
Moro E, Volkmann J, König I R, Winkler S, Hiller A, Hassin-Baer S, Herzog J, Schnitzler A, Lohmann K, Pinsker M O, Voges J, Djarmatic A, Seibler P, Lozano A M, Rogaeva E, Lang A E, Deuschl G, Klein C
Abstract excerpt
OBJECTIVES: To study the frequency of different gene mutations in patients with early-onset parkinsonism and bilateral subthalamic nucleus deep brain stimulation (STN-DBS) and the short- and long-term surgical outcome in mutation-positive (MUT+) and -negative (MUT-) patients. METHODS: Eighty patients with disease onset at age <or= 45 years and bilateral STN-DBS were screened for mutations in the Parkin gene and...
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