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Progression and treatment of a series of patients with advanced LRRK2-associated Parkinson's disease.

Neurologia - 1 Jun 2023

Fernández-Pajarín G, Sesar Á, Jiménez-Martín I, Ares B, Castro A

Abstract excerpt

INTRODUCTION: LRRK2 mutations have traditionally been associated with a benign phenotype of Parkinson's disease (PD). Favourable responses to deep brain stimulation (DBS) are reported in the advanced phase. METHODS: We performed a retrospective analysis of the clinical characteristics and progression of 13 patients with LRRK2-associated PD (13 with G2019S and 1 with I1371V). Nine patients were in the advanced...

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PMID: 35644844
DOI: 10.1016/j.nrleng.2020.06.014

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