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The LRRK2 G2019S mutation status does not affect the outcome of subthalamic stimulation in patients with Parkinson's disease.

Parkinsonism & related disorders - 1 Nov 2013

Greenbaum Lior, Israeli-Korn Simon D, Cohen Oren S, Elincx-Benizri Sandra, Yahalom Gilad, Kozlova Evgenia, Strauss Hanna, Molshatzki Noa, Inzelberg Rivka, Spiegelmann Roberto, Israel Zvi, Hassin-Baer Sharon

Abstract excerpt

BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for advanced Parkinson's disease (PD). The most common genetic mutation associated with PD identified to date is the G2019S mutation of the LRRK2 gene, which is highly prevalent in the Ashkenazi Jewish population. The effect of STN-DBS surgery in patients carrying this mutation has not been systematically studied....

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PMID: 23932063
DOI: 10.1016/j.parkreldis.2013.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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