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Article

Subthalamic nucleus stimulation is efficacious in patients with Parkinsonism and LRRK2 mutations.

Movement disorders : official journal of the Movement Disorder Society - 1 Jan 2007

Schüpbach Michael, Lohmann Ebba, Anheim Mathieu, Lesage Suzanne, Czernecki Virginie, Yaici Sadek, Worbe Yulia, Charles Perrine, Welter Marie-Laure, Pollak Pierre, Dürr Alexandra, Agid Yves, Brice Alexis

Abstract excerpt

Stimulation of the subthalamic nucleus (STN) improves motor signs in patients with levodopa-responsive Parkinson's disease (PD). Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause Parkinsonism. We assessed 69 patients under STN stimulation and found heterozygous LRRK2 mutations in 9 (G2019S in 8 and T2031S in 1). The age at onset of PD, the clinical characteristics before or after neurosurgery, and...

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PMID: 17080443
DOI: 10.1002/mds.21178

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