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Article

Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development.

PloS one - 1 Jan 2013

Gavrilov Svetlana, Harvey Richard P, Papaioannou Virginia E

Abstract excerpt

Members of the T-box family of transcription factors are important regulators orchestrating the complex regionalization of the developing mammalian heart. Individual mutations in Tbx20 and Tbx3 cause distinct congenital heart abnormalities in the mouse: Tbx20 mutations result in failure of heart looping, developmental arrest and lack of chamber differentiation, while hearts of Tbx3 mutants progress further, loop...

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Identifiers

PMID: 23936153
DOI: 10.1371/journal.pone.0070149
PMCID: PMC3723716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of genetic interaction between Tbx20 and Tbx3 in early mouse heart development.PMID 23936153Read ↗

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Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.Semantic proximity Read ↗

Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy.Semantic proximity Read ↗

The Role of Tbx20 in Cardiovascular Development and FunctionSemantic proximity Read ↗

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formationSemantic proximity Read ↗

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.Semantic proximity Read ↗

Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart RemodelingSemantic proximity Read ↗

Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.Semantic proximity Read ↗

Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.Semantic proximity Read ↗

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read ↗

Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte functionSemantic proximity Read ↗

Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development.Semantic proximity Read ↗

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