Article
Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2012
Frank Deborah U, Carter Kandis L, Thomas Kirk R, Burr R Michael, Bakker Martijn L, Coetzee William A, Tristani-Firouzi Martin, Bamshad Michael J, Christoffels Vincent M, Moon Anne M
Abstract excerpt
TBX3 is critical for human development: mutations in TBX3 cause congenital anomalies in patients with ulnar-mammary syndrome. Data from mice and humans suggest multiple roles for Tbx3 in development and function of the cardiac conduction system. The mechanisms underlying the functional developmen...
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