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Article

Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development.

Development (Cambridge, England) - 1 Oct 2004

Harrelson Zachary, Kelly Robert G, Goldin Sarah N, Gibson-Brown Jeremy J, Bollag Roni J, Silver Lee M, Papaioannou Virginia E

Abstract excerpt

Tbx2 is a member of the T-box transcription factor gene family, and is expressed in a variety of tissues and organs during embryogenesis. In the developing heart, Tbx2 is expressed in the outflow tract, inner curvature, atrioventricular canal and inflow tract, corresponding to a myocardial zone that is excluded from chamber differentiation at 9.5 days post coitus (dpc). We have used targeted mutagenesis in mice...

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Source

Identifiers

PMID: 15459098
DOI: 10.1242/dev.01378

Genes

TBX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development.PMID 15459098Read ↗

Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.Semantic proximity Read ↗

Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formationSemantic proximity Read ↗

Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development.Semantic proximity Read ↗

Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal.Semantic proximity Read ↗

Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.Semantic proximity Read ↗

T‐box transcription factor Tbx2 represses differentiation and formation of the cardiac chambersSemantic proximity Read ↗

Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis.Semantic proximity Read ↗

Tbx2 and Tbx3 Regulate the Dynamics of Cell Proliferation during Heart RemodelingSemantic proximity Read ↗

Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.Semantic proximity Read ↗

The Role of Tbx20 in Cardiovascular Development and FunctionSemantic proximity Read ↗

Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial–mesenchymal transition via Bmp2Semantic proximity Read ↗

Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndromeSemantic proximity Read ↗

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