Article
Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development.
Development (Cambridge, England) - 1 Oct 2004
Harrelson Zachary, Kelly Robert G, Goldin Sarah N, Gibson-Brown Jeremy J, Bollag Roni J, Silver Lee M, Papaioannou Virginia E
Abstract excerpt
Tbx2 is a member of the T-box transcription factor gene family, and is expressed in a variety of tissues and organs during embryogenesis. In the developing heart, Tbx2 is expressed in the outflow tract, inner curvature, atrioventricular canal and inflow tract, corresponding to a myocardial zone t...
Topics
- Animals
- Body Patterning
- Cell Differentiation
- Gene Targeting
- Heart
- Heart Atria
- Heart Ventricles
- Limb Deformities, Congenital
- Mice
- Mutation
- T-Box Domain Proteins