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Article

DNA topoisomerase I affects polycomb group protein-mediated epigenetic regulation and plant development by altering nucleosome distribution in Arabidopsis.

The Plant cell - 1 Jul 2014

Liu Xigang, Gao Lei, Dinh Thanh Theresa, Shi Ting, Li Dongming, Wang Ruozhong, Guo Lin, Xiao Langtao, Chen Xuemei

Abstract excerpt

It has been perplexing that DNA topoisomerases, enzymes that release DNA supercoils, play specific roles in development. In this study, using a floral stem cell model in Arabidopsis thaliana, we uncovered a role for TOPOISOMERASE1α (TOP1α) in Polycomb Group (PcG) protein-mediated histone 3 lysine 27 trimethylation (H3K27me3) at, and transcriptional repression of, the stem cell maintenance gene WUSCHEL (WUS). We...

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Identifiers

PMID: 25070639
DOI: 10.1105/tpc.114.124941
PMCID: PMC4145115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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