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Article

Topoisomerase II is required for the production of long Pol II gene transcripts in yeast.

Nucleic acids research - 1 Sept 2012

Joshi Ricky S, Piña Benjamin, Roca Joaquim

Abstract excerpt

The extent to which the DNA relaxation activities of eukaryotic topoisomerases (topo I and topo II) are redundant during gene transcription is unclear. Although both enzymes can often substitute for each other in vivo, studies in vitro had revealed that the DNA cross-inversion mechanism of topo II relaxes chromatin more efficiently than the DNA strand-rotation mechanism of topo I. Here, we show that the...

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Identifiers

PMID: 22718977
DOI: 10.1093/nar/gks626
PMCID: PMC3439932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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