Article
A novel histone deacetylase complex in the control of transcription and genome stability.
Molecular and cellular biology - 15 Sept 2014
Zilio Nicola, Codlin Sandra, Vashisht Ajay A, Bitton Danny A, Head Steven R, Wohlschlegel James A, Bähler Jürg, Boddy Michael N
Abstract excerpt
The acetylation state of histones, controlled by histone acetyltransferases (HATs) and deacetylases (HDACs), profoundly affects DNA transcription and repair by modulating chromatin accessibility to the cellular machinery. The Schizosaccharomyces pombe HDAC Clr6 (human HDAC1) binds to different sets of proteins that define functionally distinct complexes: I, I', and II. Here, we determine the composition,...
Topics
- Cell Cycle Proteins
- Chromatin
- Chromosomes, Fungal
- Epigenesis, Genetic
- Gene Expression Regulation, Fungal
- Genome, Fungal
- Genomic Instability
- Histone Deacetylases
- Meiosis
- Phenotype
- RNA, Fungal
- RNA, Long Noncoding
- Schizosaccharomyces