Article
Genetic landscape of open chromatin in yeast.
PLoS genetics - 1 Jan 2013
Lee Kibaick, Kim Sang Cheol, Jung Inkyung, Kim Kwoneel, Seo Jungmin, Lee Heun-Sik, Bogu Gireesh K, Kim Dongsup, Lee Sanghyuk, Lee Byungwook, Choi Jung Kyoon
Abstract excerpt
Chromatin regulation underlies a variety of DNA metabolism processes, including transcription, recombination, repair, and replication. To perform a quantitative genetic analysis of chromatin accessibility, we obtained open chromatin profiles across 96 genetically different yeast strains by FAIRE (formaldehyde-assisted isolation of regulatory elements) assay followed by sequencing. While 5∼10% of open chromatin...
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