Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors.

Nucleic acids research - 1 Aug 2010

Rodríguez-Gil Alfonso, García-Martínez José, Pelechano Vicent, Muñoz-Centeno María de la Cruz, Geli Vincent, Pérez-Ortín José E, Chávez Sebastián

Abstract excerpt

In order to study the intragenic profiles of active transcription, we determined the relative levels of active RNA polymerase II present at the 3'- and 5'-ends of 261 yeast genes by run-on. The results obtained indicate that the 3'/5' run-on ratio varies among the genes studied by over 12 log(2) units. This ratio seems to be an intrinsic characteristic of each transcriptional unit and does not significantly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Fungal
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oligonucleotide Array Sequence Analysis

Share to RNA Polymerase II

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Transcription, Genetic

Share to Transcriptional Elongation Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 20385590
DOI: 10.1093/nar/gkq215
PMCID: PMC2919717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors.PMID 20385590Read ↗

RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast.Semantic proximity Read ↗

Genetic analysis of polyadenylation patterns reveals distinct classes of yeast genes and local chromatin effects on Pol II elongation.Semantic proximity Read ↗

Topoisomerase II regulates yeast genes with singular chromatin architectures.Semantic proximity Read ↗

Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Size selected NET‐Seq reveals a conserved architecture of transcription units around yeast genes.Semantic proximity Read ↗

Compromised RNA polymerase III complex assembly leads to local alterations of intergenic RNA polymerase II transcription in Saccharomyces cerevisiae.Semantic proximity Read ↗

Distinct activated and non-activated RNA polymerase II complexes in yeast.Semantic proximity Read ↗

The ribosome assembly gene network is controlled by the feedback regulation of transcription elongation.Semantic proximity Read ↗

Wide-ranging and unexpected consequences of altered Pol II catalytic activity in vivo.Semantic proximity Read ↗

Chromatin-sensitive cryptic promoters encode alternative protein isoforms in yeastSemantic proximity Read ↗

In vivo evidence that defects in the transcriptional elongation factors RPB2, TFIIS, and SPT5 enhance upstream poly(A) site utilization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.