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Article

From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.

Cell - 15 Aug 2013

Braberg Hannes, Jin Huiyan, Moehle Erica A, Chan Yujia A, Wang Shuyi, Shales Michael, Benschop Joris J, Morris John H, Qiu Chenxi, Hu Fuqu, Tang Leung K, Fraser James S, Holstege Frank C P, Hieter Philip, Guthrie Christine, Kaplan Craig D, Krogan Nevan J

Abstract excerpt

RNA polymerase II (RNAPII) lies at the core of dynamic control of gene expression. Using 53 RNAPII point mutants, we generated a point mutant epistatic miniarray profile (pE-MAP) comprising ∼60,000 quantitative genetic interactions in Saccharomyces cerevisiae. This analysis enabled functional assignment of RNAPII subdomains and uncovered connections between individual regions and other protein complexes. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23932120
DOI: 10.1016/j.cell.2013.07.033
PMCID: PMC3932829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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