Article
Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution.
Cell systems - 27 Apr 2016
Utrilla Jose, O'Brien Edward J, Chen Ke, McCloskey Douglas, Cheung Jacky, Wang Harris, Armenta-Medina Dagoberto, Feist Adam M, Palsson Bernhard O
Abstract excerpt
Pleiotropic regulatory mutations affect diverse cellular processes, posing a challenge to our understanding of genotype-phenotype relationships across multiple biological scales. Adaptive laboratory evolution (ALE) allows for such mutations to be found and characterized in the context of clear selection pressures. Here, several ALE-selected single-mutation variants in RNA polymerase (RNAP) of Escherichia coli are...
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