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Article

RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast.

Genome biology - 1 Jan 2010

Kim Tae Soo, Liu Chih Long, Yassour Moran, Holik John, Friedman Nir, Buratowski Stephen, Rando Oliver J

Abstract excerpt

BACKGROUND: The use of genome-wide RNA abundance profiling by microarrays and deep sequencing has spurred a revolution in our understanding of transcriptional control. However, changes in mRNA abundance reflect the combined effect of changes in RNA production, processing, and degradation, and thus, mRNA levels provide an occluded view of transcriptional regulation. RESULTS: To partially disentangle these issues,...

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Identifiers

PMID: 20637075
DOI: 10.1186/gb-2010-11-7-r75
PMCID: PMC2926786

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