Article
Parkinson disease phenotype in Ashkenazi Jews with and without LRRK2 G2019S mutations.
Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2013
Alcalay Roy N, Mirelman Anat, Saunders-Pullman Rachel, Tang Ming-X, Mejia Santana Helen, Raymond Deborah, Roos Ernest, Orbe-Reilly Martha, Gurevich Tanya, Bar Shira Anat, Gana Weisz Mali, Yasinovsky Kira, Zalis Maayan, Thaler Avner, Deik Andres, Barrett Matthew James, Cabassa Jose, Groves Mark, Hunt Ann L, Lubarr Naomi, San Luciano Marta, Miravite Joan, Palmese Christina, Sachdev Rivka, Sarva Harini, Severt Lawrence, Shanker Vicki, Swan Matthew Carrington, Soto-Valencia Jeannie, Johannes Brooke, Ortega Robert, Fahn Stanley, Cote Lucien, Waters Cheryl, Mazzoni Pietro, Ford Blair, Louis Elan, Levy Oren, Rosado Llency, Ruiz Diana, Dorovski Tsvyatko, Pauciulo Michael, Nichols William, Orr-Urtreger Avi, Ozelius Laurie, Clark Lorraine, Giladi Nir, Bressman Susan, Marder Karen S
Abstract excerpt
The phenotype of Parkinson's disease (PD) in patients with and without leucine-rich repeat kinase 2 (LRRK2) G2019S mutations reportedly is similar; however, large, uniformly evaluated series are lacking. The objective of this study was to characterize the clinical phenotype of Ashkenazi Jewish (AJ) PD carriers of the LRRK2 G2019S mutation. We studied 553 AJ PD patients, including 65 patients who were previously...
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