Article
Dyskinesias in patients with Parkinson's disease: effect of the leucine-rich repeat kinase 2 (LRRK2) G2019S mutation.
Parkinsonism & related disorders - 1 Nov 2012
Yahalom Gilad, Kaplan Natalie, Vituri Aya, Cohen Oren S, Inzelberg Rivka, Kozlova Evgenia, Korczyn Amos D, Rosset Saharon, Friedman Eitan, Hassin-Baer Sharon
Abstract excerpt
BACKGROUND: While Parkinson's disease (PD) phenotype in leucine-rich repeat kinase 2 gene (LRRK2)-associated and sporadic PD seems similar, there is paucity of data on the possible effect of mutations in LRRK2 on response to and complications of dopaminergic therapy. OBJECTIVE: To assess the impact of the LRRK2 Gly2019Ser (G2019S) carrier status on the time to the onset of levodopa-induced dyskinesias (LID)....
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