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A pooling-based approach to mapping genetic variants associated with DNA methylation.

Genome research - 1 Jun 2015

Kaplow Irene M, MacIsaac Julia L, Mah Sarah M, McEwen Lisa M, Kobor Michael S, Fraser Hunter B

Abstract excerpt

DNA methylation is an epigenetic modification that plays a key role in gene regulation. Previous studies have investigated its genetic basis by mapping genetic variants that are associated with DNA methylation at specific sites, but these have been limited to microarrays that cover <2% of the genome and cannot account for allele-specific methylation (ASM). Other studies have performed whole-genome bisulfite...

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Computational Biology
Computer Simulation
Databases, Genetic
DNA Methylation
Epigenesis, Genetic

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PMID: 25910490
DOI: 10.1101/gr.183749.114
PMCID: PMC4448686

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