Article
Proteolytic processing of TGFalpha redirects its mitogenic activity: the membrane-anchored form is autocrine, the secreted form is paracrine.
Biochimica et biophysica acta - 15 Apr 2005
Roh Meejeon, Paterson Andrew J, Liu Kan, McAndrew Joanne, Chin Edward, Kudlow Jeffrey E
Abstract excerpt
Wild-type transforming growth factor alpha (TGFalpha) expression in lactotrope cells in the pituitary gland led to lactotrope-specific pituitary hyperplasia and adenomata. To indicate whether the EGF receptor is involved in this TGFalpha-mediated phenotype, we bred TGFalpha mice with mice expressing the cytoplasmic truncated-EGF receptor (EGFR-tr), which is dominant-negative in other models. These bitransgenic...
Topics
- Animals
- CHO Cells
- Cell Division
- Cell Membrane
- Coloring Agents
- Cricetinae
- Cytoplasm
- ErbB Receptors
- Hyperplasia
- Mice
- Mice, Transgenic