Cell transformation by kFGF requires secretion but not glycosylation.

doi:10.1083/jcb.115.2.547

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Article

Cell transformation by kFGF requires secretion but not glycosylation.

The Journal of cell biology - 1 Oct 1991

Fuller-Pace F, Peters G, Dickson C

Abstract excerpt

The Kfgf gene, which encodes a member of the fibroblast growth factor family, was originally discovered by assaying human tumor DNA for dominantly transforming oncogenes. The 22-kD kFGF product contains a single site for asparagine-linked glycosylation and an amino-terminal signal peptide for vectorial synthesis into the endoplasmic reticulum and eventual secretion. To determine whether these features are...

Topics

Animals
Asparagine
Base Sequence
Cell Line
Cell Transformation, Neoplastic
DNA Replication
Electric Stimulation
Fibroblast Growth Factor 4
Fibroblast Growth Factors
Gene Expression
Glycosylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Proto-Oncogene Proteins

Receptors, Cell Surface

Receptors, Fibroblast Growth Factor

Suramin

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1655808
DOI: 10.1083/jcb.115.2.547
PMCID: PMC2289164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1655808-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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