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Article

Ordered accumulation of mutations conferring resistance to sulfadoxine-pyrimethamine in the Plasmodium falciparum parasite.

The Journal of infectious diseases - 1 Jan 2014

Mita Toshihiro, Ohashi Jun, Venkatesan Meera, Marma Aung Swi Prue, Nakamura Masatoshi, Plowe Christopher V, Tanabe Kazuyuki

Abstract excerpt

BACKGROUND: Monitoring the prevalence of drug resistant Plasmodium falciparum is essential for effective malaria control. Resistance to pyrimethamine and sulfadoxine increases as mutations accumulate in the parasite genes encoding dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps)...

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Source

Identifiers

PMID: 23922363
DOI: 10.1093/infdis/jit415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23922363-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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