Article
Prediction of Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in vivo by mutations in the dihydrofolate reductase and dihydropteroate synthetase genes: a comparative study between sites of differing endemicity.
The American journal of tropical medicine and hygiene - 1 Dec 2003
Alifrangis Michael, Enosse Sonja, Khalil Insaf F, Tarimo Donath S, Lemnge Martha M, Thompson Richardo, Bygbjerg Ib C, Rønn Anita M
Abstract excerpt
Plasmodium falciparum resistance to sulfadoxine/pyrimethamine (S/P) is due to mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhfr) genes. Large-scale screening of the prevalence of these mutations could facilitate the surveillance of the level of S/P resistance in vivo. The prevalence of mutations in dhfr and dhps in relation to S/P efficacy was studied in four sites of differing...
Topics
- Adolescent
- Adult
- Aged
- Animals
- Antimalarials
- Biomarkers
- Child
- Dihydropteroate Synthase
- Drug Combinations
- Drug Resistance, Multiple