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Article

Low-dose treatment with sulfadoxine-pyrimethamine combinations selects for drug-resistant Plasmodium falciparum strains.

Antimicrobial agents and chemotherapy - 1 Sept 1999

Kun J F, Lehman L G, Lell B, Schmidt-Ott R, Kremsner P G

Abstract excerpt

A total of 252 children were enrolled in a drug trial to assess the effect of minimal doses of sulfadoxine (Sdx) and pyrimethamine (Pyr). Parasite samples isolated from these patients were analyzed before and after treatment to investigate the level of drug-resistant strains. The parasite genes encoding dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) were assayed for point mutations that are...

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Source

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Identifiers

PMID: 10471565
DOI: 10.1128/AAC.43.9.2205
PMCID: PMC89447

Genes

DHFR
DHPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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