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Article

Stepwise acquisition of pyrimethamine resistance in the malaria parasite.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2009

Lozovsky Elena R, Chookajorn Thanat, Brown Kyle M, Imwong Mallika, Shaw Philip J, Kamchonwongpaisan Sumalee, Neafsey Daniel E, Weinreich Daniel M, Hartl Daniel L

Abstract excerpt

The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance using an approach in which all possible mutational intermediates were created by site-directed mutagenesis and assayed for their level of drug resistance. The coding sequence for...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19587242
DOI: 10.1073/pnas.0905922106
PMCID: PMC2715478

Genes

DHFR

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Source receipt: pubmed, retrieved 7 Sept 2026.

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