Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis.

Cancer research - 15 Sept 2013

Cronin Julia C, Watkins-Chow Dawn E, Incao Art, Hasskamp Joanne H, Schönewolf Nicola, Aoude Lauren G, Hayward Nicholas K, Bastian Boris C, Dummer Reinhard, Loftus Stacie K, Pavan William J

Abstract excerpt

The transcription factor SOX10 is essential for survival and proper differentiation of neural crest cell lineages, where it plays an important role in the generation and maintenance of melanocytes. SOX10 is also highly expressed in melanoma tumors, but a role in disease progression has not been e...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to Cell Cycle
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Melanoma

Share to Real-Time Polymerase Chain Reaction

Share to Receptors, Metabotropic Glutamate

Share to SOXE Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 23913827
DOI: 10.1158/0008-5472.CAN-12-4620
PMCID: PMC3803156

Genes

SOX10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23913827-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis.PMID 23913827Read ↗

DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype.Semantic proximity Read ↗

Identification and functional analysis of SOX10 phosphorylation sites in melanomaSemantic proximity Read ↗

Specific <i>SOX10</i> enhancer elements modulate phenotype plasticity and drug resistance in melanomaSemantic proximity Read ↗

SOX5 is involved in balanced MITF regulation in human melanoma cells.Semantic proximity Read ↗

Linking SOX10 to a slow-growth resistance phenotype.Semantic proximity Read ↗

Cross-species analysis reveals unique and shared roles of Sox9 and Sox10 (SOXE family) transcription factors in melanomaSemantic proximity Read ↗

Loss of <i>prdm1a</i> accelerates melanoma onset and progressionSemantic proximity Read ↗

SOX10 and microRNAs: decoding their interplay in regulating melanoma plasticitySemantic proximity Read ↗

CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human MelanomaSemantic proximity Read ↗

Targeting SOX10-deficient cells to reduce the dormant-invasive phenotype state in melanoma.Semantic proximity Read ↗

p300 KAT regulates SOX10 stability and function in human melanomaSemantic proximity Read ↗

SOX4 inhibits GBM cell growth and induces G0/G1 cell cycle arrest through Akt-p53 axisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.