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Article

DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype.

JCI insight - 10 Oct 2022

Sanna Adriana, Phung Bengt, Mitra Shamik, Lauss Martin, Choi Jiyeon, Zhang Tongwu, Njauw Ching-Ni, Cordero Eugenia, Harbst Katja, Rosengren Frida, Cabrita Rita, Johansson Iva, Isaksson Karolin, Ingvar Christian, Carneiro Ana, Brown Kevin, Tsao Hensin, Andersson My, Pietras Kristian, Jönsson Göran

Abstract excerpt

Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug-tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte-specific gene expression and increase of mesenchymal markers. Two crucial transcription factors, microphthalmia-associated transcription factor (MITF) and SRY-box transcription...

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Identifiers

PMID: 36040798
DOI: 10.1172/jci.insight.156577
PMCID: PMC9675437

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