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Article

CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma

8 Oct 2018

Abstract excerpt

Abstract Cancers are composed of heterogeneous subpopulations with various tumor-initiating capacities, yet key stem cell genes associated with enhanced tumor-initiating capacities and their regulatory mechanisms remain elusive. Here, we analyzed patient-derived xenografts from melanoma, colon, and pancreatic cancer tissues and identified enrichment of tumor-initiating cells in MHC class I-hi cells, where CDK1, a...

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PMID: 30297536
DOI: 10.1158/0008-5472.can-18-0330

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