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Article

K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells.

Molecular cell - 8 Aug 2013

Linares Juan F, Duran Angeles, Yajima Tomoko, Pasparakis Manolis, Moscat Jorge, Diaz-Meco Maria T

Abstract excerpt

The ability of cells to respond to changes in nutrient availability is critical for an adequate control of metabolic homeostasis. Mammalian target of rapamycin complex 1 (mTORC1) is a central complex kinase in these processes. The signaling adaptor p62 binds raptor, and integral component of the mTORC1 pathway. p62 interacts with TNF receptor associated factor 6 (TRAF6) and is required for mTORC1 translocation to...

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Source

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Identifiers

PMID: 23911927
DOI: 10.1016/j.molcel.2013.06.020
PMCID: PMC3971544

Genes

TRAF6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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