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The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer

22 Jun 2021

Abstract excerpt

p62 is a highly conserved, multi-domain, and multi-functional adaptor protein critically involved in several important cellular processes. Via its pronounced domain architecture, p62 binds to numerous interaction partners, thereby influencing key pathways that regulate tissue homeostasis, inflammation, and several common diseases including cancer. Via binding of ubiquitin chains, p62 acts in an anti-inflammatory...

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PMID: 34206503
DOI: 10.3390/biomedicines9070707

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