Article
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
Science (New York, N.Y.) - 24 Mar 2017
Castellano Brian M, Thelen Ashley M, Moldavski Ofer, Feltes McKenna, van der Welle Reini E N, Mydock-McGrane Laurel, Jiang Xuntian, van Eijkeren Robert J, Davis Oliver B, Louie Sharon M, Perera Rushika M, Covey Douglas F, Nomura Daniel K, Ory Daniel S, Zoncu Roberto
Abstract excerpt
The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that becomes activated at the lysosome in response to nutrient cues. Here, we identify cholesterol, an essential building block for cellular growth, as a nutrient input that drives mTORC1 recruitment and activation at the lysosomal surface. The lysosomal transmembrane protein, SLC38A9, is required for mTORC1...
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